Journal article

Proton Pump Inhibitors and Preeclampsia Risk Among 157 720 Women

Roxanne Hastie, Lina Bergman, Catherin A Cluver, Anna Wikman, Natalie J Hannan, Susan P Walker, Anna-Karin Wikström, Stephen Tong, Susanne Hesselman

Hypertension | Wolters Kluwer | Published : 2019

DOI: 10.1161/hypertensionaha.118.12547

Abstract

Preeclampsia is a hypertensive disorder of pregnancy with a high rate of maternal and neonatal morbidity and mortality. The only definite treatment is delivery. Preclinical investigations have identified proton pump inhibitors (PPIs), which are commonly used to treat reflux during pregnancy, as a potential treatment for preeclampsia. The aim of this study was to determine the association between PPI use during pregnancy and preeclampsia risk in a population-based register cohort. Using the Swedish Pregnancy Register, we conducted a cohort study of nulliparous pregnant women delivering from January 2013 to July 2017. Associations between PPI use and preeclampsia were investigated using logist..

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University of Melbourne Researchers

A/Prof Roxanne Hastie Author

Prof Natalie Hannan Author

Prof Susan Walker Author

Prof Stephen Tong Author

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Keywords

4.1 Discovery and Preclinical Testing of Markers and Technologies

Contraception/reproduction

Maternal Morbidity and Mortality

3215 Reproductive Medicine

Reproductive Health and Childbirth

32 Biomedical and Clinical Sciences

2.1 Biological and Endogenous Factors

Infant Mortality

3 Good Health and Well Being

Perinatal Period - Conditions Originating in Perinatal Period

Maternal Health

Pediatric Research Initiative